About Collagenius….

Collagenius is a very high purity combination formulation, the main component of which is a type I collagen hydrolysate (with small amounts of type III collagen).

Produced with superior technology and patented
Peptan
collagen peptides promise more efficient absorption and bioavailability than the same amount of average collagen preparations. Behind the collagen hydrolysate used in our formulation
clinical trials
that give the product credibility.

The product is primarily developed for active lifestyles and dedicated athletes. In addition to collagen, it contains other additives such as
magnesium, copper
and
manganese
– which make the collagen synthesis process more efficient. The also high purity
chondroitin-
and
glucosamine sulphate
can also support cartilage metabolism and cartilage regeneration.

The preparation contains antioxidants –
blue grape seed extract
and
vitamin C
– in high doses to reduce the significant oxidative damage caused during exercise and to improve the
hyaluronic acid
can also have a beneficial effect on stressed joints.

Chemical basics

Collagen belongs to a group of proteins that are mainly made up of three types of amino acids, glycine, proline and hydroxyproline. There are 29 types of collagens, of which types I, II and III are the most commonly known.

Collagen I is the most abundant type of collagen, as it is present in essentially all tissues as a general binding agent (tendons, muscles, bones, vascular walls, skin, cartilage, teeth, hair, corneas, and all scar tissues). Collagen III is the type of collagen found in granulation tissue and is produced by young fibroblast cells before it is converted into the more structurally strong collagen I. And collagen II is mainly present in the vitreous cartilage (the material of load-bearing joint surfaces), accounting for about half of the proteins found there.

The individual collagen molecules (tropocollagen) assemble into larger collagen chains that form collagen fibrils, or fibres. These 300nm-long filaments are made up of triple-stranded polypeptide chains (showing the structure of a “left-handed” helix). These three-strand “left-handed” spirals are arranged in a larger “right-handed” spiral structure, and are then interconnected, called a “left-handed” spiral. creating super-spirals. This complex spatial structure is stabilised by hydrogen bonds. This is called collagen microfibrils (collagen fibres).

Collagen production process

1. step forward: Intracellular (intracellular process): within cells, the triple-stranded collagen helix – alpha 1 and alpha 2 helices – is produced in the endoplasmic reticulum. The amino acids lysine and proline are hydroxylated (vitamin C plays a key role in this process, acting as a cofactor: for each hydroxylation, the body uses one molecule of ascorbic acid). Two alpha 1 chains and one alpha 2 chain form the triple helix structure. This is the
   procollagen
   is transferred from the endoplasmic reticulum to the Golgi apparatus, which packages this procollagen and secretes it from the cell.
2. step forward: Extracellular (extracellular process): the procollagen peptidase enzyme is involved in the
   tropocollagen
   chain. The numerous tropocollagen chain cross-links through the formation of the
   collagen fibrils
   and the collagen fibrils form the collagen fibrils in groups to form the
   collagen fibres
   at.

Vitamin C deficiency leads to scurvy, a disease in which the defective collagen structure does not allow the formation of connective tissue elements of adequate tensile strength and strength (resulting in tooth loss, bleeding gums, wound healing disorders, bone structure abnormalities – just a few of the symptoms highlighted, all due to the disruption of collagen production, resulting in severe and painful symptoms).

Life science basics

Collagen makes up one third of the proteins in the human body (about 80% of skin, about 80% of tendons and ligaments, about 30% of bones, about 10% of muscle and about 50% of articular cartilage).

Our bodies can produce collagen up to a certain age, but as the years go by, the amount of collagen produced decreases to meet the body’s need for collagen. endogenous synthesis (which also provides the body with the amino acid building blocks to assemble the final collagen chains, for example, by breaking down hamburger), and we are increasingly in need of adequate quality exogenous collagen source. The (complex, long) collagen chains in our diet need to be broken down enzymatically in order to be used by the body. The big advantage of collagen hydrolysates is that this process takes place during the production of collagen peptides, so the end result is a much better absorbed collagen source with a much more optimal bioavailability. Some of the collagen peptides in the hydrolysate enter the bloodstream without further degradation and thus reach the target cells (which triggers a strong stimulus for increased collagen production in collagen-producing target cells), while some are broken down into amino acids that serve as building blocks for further synthesis. The process of how collagen peptides pass through the intestinal wall is not yet fully understood, but some clinical studies raise the possibility that increased physical activity may induce this increased intestinal wall permeability, promoting the absorption of ‘larger collagen building blocks’. With this in mind, it is recommended to consume collagen peptides before or during exercise!

The effect of collagen

The loss of collagen also has visible signs (wrinkling with age, loss of skin firmness), but these processes also occur in other parts of the body (muscles, tendons, ligaments, bones, etc.The only thing we notice is that our bones are more fragile than they used to be, and we tend to develop muscle tears, muscle strains, ligament injuries and tendon injuries more easily than when we were younger. Overall, over time, we become more vulnerable, our resilience decreases, and we find it harder to recover from injuries. Unfortunately, this is a physiological process that cannot be stopped or reversed, but it is possible to slow down the rate of this decline.

Eat a varied, protein-rich diet, get the vitamins and trace elements you need on a daily basis, and take concentrated collagen hydrolysates at least as a course throughout the year.

Who is collagen hydrolysate recommended for?

In principle, it is recommended for use over 30 years of age, primarily in combination with the unflavoured Collagenius product. The two products together have a very high collagen peptide intake, 15 000mg per serving, plus Peptan, which is believed to be the best quality collagen peptide in Europe. Its primary action is on the skin, which can improve its elasticity, firmness and hydration. However, joints, ligaments, tendons, muscles and bones can also benefit from the high collagen peptide content, which is reinforced by other active ingredients.

What conditions and factors justify increased collagen intake?

• Active sporting life (overuse and the regular development of micro/macro-injuries place increased demands on the body in terms of regeneration, and collagen is the main building material for these regenerative processes).
• Over 45 years of age, even without sport.
• Smoking (leads to increased collagen degeneration).
• While taking steroids (leads to significant collagen degeneration).
• Increased UV exposure (causes premature ageing of the skin due to the damaging effects of UV light on collagen).
• Osteoporosis/osteopenia (bone fragility is not only due to loss of minerals, but also due to significant loss of collagen, which significantly reduces the elasticity and tensile strength of bones).
• In certain autoimmune diseases, when the body’s collagen stock also falls victim (the autoimmune process in the body causes a significant loss of collagen, the replacement of which somewhat counteracts the rate of weight loss).
• To promote the healing process of fractures, even after surgical treatment.
• After soft tissue surgery (hernia surgery, abdominal surgery, breast surgery, plastic surgery) (the body always fills the tissue deficiency with scar tissue, which requires adequate collagen replenishment).
• To promote the regeneration of tendon and ligament injuries.
• For joint pain.
• For vascular diseases (arterial and venous dilatation).
• Additional treatment for pain caused by overuse of tendons.
• For aesthetic reasons, to tone the skin and connective tissue elements (e.g. cellulite, striae, scars). Collagen taken orally has been shown to have a positive effect on skin tone and firmness. Numerous clinical studies confirm that ingested collagen does indeed make the skin firmer and more youthful, while externally applied collagen-containing skin care products have no proven effect on connective tissue collagen.
• Treatment of hair and nail fragmentation (also proven to treat non-hormonal hair loss).

Natural collagen sources

Cattle

Collagen source: I, III, IV

Parts used:gums, bones, skin, cartilage

Pigs

Collagen source: I, III

Parts used: tendons, bones, skin

Fowl

Collagen sources: I, II, III, IV, V, IX

Parts used: tendons, bones, muscle

Sea animals

Collagen source: I

Parts used: fish skins, cephalopods, armour

References:

https://www.longdom.org/open-access/effects-of-collagen-ingestion-and-their-biological-significance-2155-9600-1000504.pdf

https://www.nutraingredients.com/Article/2020/05/06/Pioneering-study-reveals-collagen-peptide-changes-during-digestion#

https://www.gelita.com/en/blog/amazingcollagen/how-are-collagen-peptides-absorbed-bod

Who is collagen hydrolysate recommended for?

In principle, it is recommended for use over 30 years of age, primarily in combination with the unflavoured Collagenius product. The two products together have a very high collagen peptide intake, 15 000mg per serving, plus Peptan, which is believed to be the best quality collagen peptide in Europe. Its primary action is on the skin, which can improve its elasticity, firmness and hydration. However, joints, ligaments, tendons, muscles and bones can also benefit from the high collagen peptide content, which is reinforced by other active ingredients.

What conditions and factors warrant increased collagen intake?

• Active sporting life (overuse and the regular development of micro/macro-injuries place increased demands on the body in terms of regeneration, and collagen is the main building material for these regenerative processes).
• Over 45 years of age, even without sport.
• Smoking (leads to increased collagen degeneration)
• While taking steroids (leads to significant collagen degeneration).
• Increased UV exposure (causes premature ageing of the skin due to the damaging effects of UV light on collagen).
• Osteoporosis/osteopenia (bone fragility is not only due to loss of minerals, but also due to significant loss of collagen, which significantly reduces the elasticity and tensile strength of bones).
• In certain autoimmune diseases, when the body’s collagen stock also falls victim (the autoimmune process in the body causes a significant loss of collagen, the replacement of which somewhat counteracts the rate of weight loss).
• To promote the healing process of fractures, even after surgical treatment.
• After soft tissue surgery (hernia surgery, abdominal surgery, breast surgery, plastic surgery) (the body always fills the tissue deficiency with scar tissue, which requires adequate collagen replenishment).
• To promote the regeneration of tendon and ligament injuries.
• For joint pain.
• For vascular diseases (arterial and venous dilatation).
• Additional treatment for pain caused by overuse of tendons.
• For aesthetic reasons, to tone the skin and connective tissue elements (e.g. cellulite, striae, scars). Collagen taken orally has been shown to have a positive effect on skin tone and firmness. Numerous clinical studies confirm that ingested collagen does indeed make the skin firmer and more youthful, while externally applied collagen-containing skin care products have no proven effect on connective tissue collagen.
• Treatment of hair and nail fragmentation (also proven to treat non-hormonal hair loss).

Ingredients

Components and their role:

Collagen peptides (enzymatically hydrolysed bovine collagen): responsible for the tensile strength of muscles, tendons, ligaments, bones and for the formation of the proper connective tissue structure. It is also present in large amounts in the cartilage envelope of joints, providing elasticity to cartilage tissue. Last but not least, it also plays an important role in the development of skin firmness, elasticity and resistance to external influences.

Glucosamine sulphate: another component of cartilage of outstanding importance.

Chondroitin sulphate: one of the most important inorganic constituents of cartilage.

Hialuronic acid: oral hyaluronic acid has a natural anti-inflammatory effect (reduces cytokine levels), is an important component of synovial fluid and has been shown in several clinical studies to improve skin elasticity and turgor.

Proanthocyanidins (blue grape seed powder): a powerful antioxidant ingredient that improves the elasticity of blood vessel walls and the resistance of cells to free radicals.

Vitamin C: plays an important role in the formation of properly structured collagen chains, is a powerful antioxidant and has a positive effect on the immune system.

Magnesium: essential for the proper functioning of the skeletal and cardiac muscles.

Manganese: plays a key role in neutralising free radicals and also improves the bioavailability of protein-rich foods.

Copper: a compound essential for neutralising free radicals and plays an essential role in the absorption of iron and vitamin C.

Inulin: as a natural fibre, it provides a good habitat and nutrition for our gut flora, which is essential for its proper functioning. From inulinis considered a very healthy sugar substitute, as it plays an important role in the healthy functioning of the intestinal tract, helps prevent the development of malignant intestinal tumours, aids calcium absorption, contributes to proper metabolic processes, promoting weight loss (all the more so as it also directly reduces the level of the hunger hormone ghrelin). As the intestinal tract is essentially our largest immune organ, its proper functioning contributes greatly to an effective immune system. It has also been shown to have a positive symptomatic effect in stubborn bowel diseases such as irritable bowel syndrome and Crohn’s disease. Last but not least, with a minimal caloric intake, it has a strong sweetening effect, but it does not represent a carbohydrate load, so it does not cause insulin spikes, and can therefore be consumed safely even by diabetics.

Pectin: a carbohydrate-like, water-soluble fibre with good water-binding capacity. It is also recommended for dieting because of this property, as it increases the feeling of fullness. It also has a detoxifying role and helps with constipation. Some research suggests that it is also useful in preventing malignant tumours of the colon.

Table of nutritional values

*RI: Reference intake for an average adult (8400kJ / 2000 kcal)

Product label

Suggested use

Add a scoop of unflavoured Collagenius to a sachet (8 g) of drink powder, then add 200-300 ml of cold water (milk or vegetable milk substitute) or other liquid and mix thoroughly, using a blender if possible. Consumption is recommended after dinner. Recommended daily amount 1-2 servings. Do not exceed the recommended daily dose!

+ = yes – = no

Possible side effects

The preparation
inulin
may cause some consumers to experience bloating, stomach pain or even diarrhoea in the initial period. This (except in gluten, and more specifically in fructan-sensitive consumers) is a temporary phenomenon, but subjective symptoms may be reduced by increased Collagenius daily doses (up to 2x10ml per day), and plenty of fluid intake will also help relieve the initial symptoms!

Contra-indications

The use of this product is not recommended in case of hypersensitivity to any of its ingredients.
Ingredients include crustaceans, gluten and traces of nuts, milk, eggs, soya, fish and sulphur dioxide! Due to its inulin content, people sensitive to inulin (fructan) should be aware of the possible accompanying symptoms of stomach pain and abdominal hiccups.

Warning

Under current EU legislation, food supplements are considered foods that are intended to supplement the traditional diet and contain nutrients in concentrated form. Although dietary supplements may have beneficial physiological effects, which may vary from one individual to another, their labelling, presentation and advertising should not be used to claim that they have a preventive or curative effect.

The product is not a substitute for a balanced, mixed diet and a healthy lifestyle!

The product does not cure diseases! The product is not a substitute for medical treatment! In case of illness, discuss use with your doctor. Do not exceed the recommended daily intake! Do not take the product if you are sensitive or allergic to any of the ingredients. It can also be taken with vitamin K antagonist blood thinners (Syncumar, Marfarin, Warfarin), but it is recommended to check the INR every week for the first month! Keep out of reach of small children!

Several times the recommended daily dose may cause diarrhoea!